Weeher m



1931 I if i it d 6 derivatives of barbituric acid, i. e.

V rated the latter) melting the mixture, mainshort time, andgcooling, all the operationsbe-v be substantially White andinodorous.

' that-is to s'ayfin an inert atmosphere.

' I It Willbe understood that various changes r thereof.

-v 2. The process which comprises causing WERNER: M. LAUTER, or BROOKLYN, NEW YORK, AssIeNon T0 E. R. SQUIBB & sons, I a OENEIW' YORK, N. Y., A oonroanrron or NEW YOR I 'AnALGEso-Hrr o'rIo oomrosrrron i no Drawing. YApplication filed ma 19, 1928. Serial 1%. 279,211. r

compositions andvpartioularly to'moleoular bituric acidin an inert atmosphere. compounds of amidopyrin, i. e. 1-phenyl-2.3- 3. The process which comprises causing dimethyl-4-dimethylamino-'5 pyrazolon, and amidopyrin to: react with ethylisopropylbar I bituric acid inflan atmosphere of carbon di- My invention relates to analgeso-hypnotic amidopyrin to react with ethylisopropylbar Oxide. V 7 I o. t X1 Y Q i 4 The process which comprises dissolving 00 I .r amldoyprin and ethylisopropylbarbituric acid in acetone, evaporating to dryness, heat-. I Y

10 l I ingthe residue above its'melting point for a wherein X X X and X represent hydro- 1 short time, and cooling, all;the operations begen or substituents therefon' ing performed in an atmosphere of carbon di- Such compounds are valuable medicinal oxide. j

agents because of their soporifi o power in the 5.1, The process Whichfcomprises dissolving presenceof pain; They are made by mixing amidopyrin and -ethylisopropylbarbituric Y the ingredients (preferably having first dis- .acid in acetone, evaporating todryness, 'heatsolved them in a common solvent and evapoing the residue above itsmelting point for a XAOOJW,

I taining it above fusion temperature for a 111 performed in an in'e'rt'atmosphere. V 7 r 20 short hile, and then cooling. I I ntestimonywhereof I afiix my signature. As.heretoforeproduced," however, these I WERNER LAUTER; compounds have been characterized by ayel- I 1 I loW color and an oflensive odor.

It is'the object of my invention toprovide I I I i r I r 25 molecular compounds of this type that shall x f I 7 y I have found that this object may be j achieved by co'nducting the steps in the preparation of jthese -compounds anaerically, I For example, the following process, if perl formed in an atmosphere oficarbon dioxide, I will, yield a substantially White and inodorous molecular compound: 58.85 grams of ami- 35 dopyrin and 46.15 gramsof ethylisopropyl barbiturio acid, are dissolved in 200 cc. of ace- 1 tone, the latter is evaporated off, and the residue is -fused,maintainedat'about 98 (lfor v I fifteen minutes, cooled, and powdered. I l p r I j? 1 I 9' I maybe made Within the scope of the appended; claims *without departing from m invention or sacrificing any of the advantages I claim: I a V j 1. A substantially white and inodorous molecular compound of amidopyrin and ethyla isopropylbarbituric acid. i V V 100 

